I found Mr. Hughes’s comments to be the most relevant, not only to science but to human experience on the whole.  His statement on ignorance and humility are something that all of us need to hear and heed.  Science is good at telling us “how” but that only to a limited extent, and never “why” which I think is the question that matters more to most people.  It is good that continue to seek new information and better explanations, but unfortunately, we don’t exhibit much humility with what we already understand or in light of our even greater lack of understanding.  Too often we either are self-aggrandizing in our knowledge and understanding or self-deprecating in our ignorance.  We need to strike a balance, appreciating what we have discovered, but also exhibiting a healthy reservation about what we do know and honesty about what we don’t.